Co Aprovel (Hydrochlorothiazide + Irbesartan) 150/12.5mg Tablet 28s (Box)

Co Aprovel 150/12.5mg Tablet is a fixed-dose combination antihypertensive medication, bringing together irbesartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic, working through two complementary mechanisms to lower blood pressure. If you're starting this medication, you're probably wondering how it fits into your routine — it's a single once-daily tablet, typically prescribed for people whose blood pressure wasn't fully controlled on just one of these medications alone, and taking it at a consistent time each day helps maintain steady blood pressure control. Some people experience dizziness, nausea, fatigue, or changes in urination, particularly when starting treatment or after a dose adjustment. It's meant to be taken consistently as part of a long-term treatment plan, with the maximum blood-pressure-lowering effect typically reached within 6 to 8 weeks. Because this combination affects both your blood vessels and kidney fluid handling, it's worth having regular check-ups with your doctor, including blood tests for kidney function and electrolytes, and discussing your full medical history before starting this medicine.

The usual dose is one tablet (150mg irbesartan/12.5mg hydrochlorothiazide) taken once daily, generally prescribed once your blood pressure isn't adequately managed on either ingredient alone at monotherapy doses. No dose adjustment is generally needed for mild to moderate kidney or liver impairment, but this medication is not to be used at all in patients with severe kidney or liver impairment.

• Dizziness
• Nausea or vomiting
• Fatigue
• Abnormal or changed urination patterns
• Increased blood urea nitrogen (BUN) or creatinine levels (identified through blood tests)
• Low blood potassium or sodium levels (uncommon)
• Fainting or low blood pressure, particularly with initial doses (uncommon)
• Rapid heartbeat (uncommon)
• Swelling of the extremities (uncommon)
• Jaundice (rare)

Store the tablets at room temperature, away from direct sunlight, heat, and moisture, in their original packaging. Keep out of reach of children.

• Take at the same time each day, with or without food, for consistent blood pressure control.
• Attend scheduled blood tests to monitor your kidney function and potassium/sodium levels.
• Tell your doctor if you become pregnant, as this medication is not suitable during pregnancy.
• Rise slowly from sitting or lying down if you notice dizziness, especially when starting treatment.
• Do not stop or adjust your dose without consulting your doctor.

Swallow the tablet with a glass of water, once daily, with or without food, at a consistent time each day. Take it exactly as prescribed by your doctor, and do not stop or adjust your dose without their guidance.

Co Aprovel 150/12.5mg Tablet generally has a shelf life of around 2–3 years from the date of manufacture when stored correctly and unopened. Always check the expiry date printed on the blister strip and outer packaging before use.

• Irbesartan 150mg – an angiotensin II receptor blocker (ARB) that relaxes blood vessels and reduces sodium/water retention
• Hydrochlorothiazide 12.5mg – a thiazide diuretic that increases the excretion of sodium, chloride, and water

• Known hypersensitivity to irbesartan, hydrochlorothiazide, or any sulfonamide-derived drugs
• Severe kidney impairment (creatinine clearance below 30mL/min)
• Severe liver impairment, biliary cirrhosis, or cholestasis
• Pregnancy, particularly contraindicated during the second and third trimesters, given documented fetal risk
• Not recommended during breastfeeding, especially when nursing a newborn or preterm infant
• Concurrent use with aliskiren-containing products in patients with diabetes or kidney impairment

This medication may interact with other blood pressure medications, lithium, NSAIDs, and medications affecting potassium levels, so it's important to inform your doctor or pharmacist about everything you're taking. Regular monitoring of your blood potassium, sodium, kidney function, and blood glucose is a routine part of safe long-term use, particularly given the diuretic component's effect on electrolyte balance.

Can I order Co Aprovel 150/12.5mg Tablet online for delivery to Singapore?
Yes, Singapore customers can purchase Co Aprovel 150/12.5mg Tablet through our online pharmacy, with orders shipped from our Malaysia-based facility.

Do I need a prescription to buy Co Aprovel 150/12.5mg Tablet?
Yes, Co Aprovel is a prescription-only medication, so please check the product listing or reach out to our pharmacist team before ordering.

How long does delivery to Singapore typically take?
Estimated delivery timeframes to Singapore will be shown at checkout based on your address and the shipping option selected.

How can I be sure the product I receive is authentic?
All products sold through our online pharmacy are sourced from authorised suppliers and manufacturers, with each order undergoing quality checks before dispatch.

What pack sizes are available for purchase?
Co Aprovel 150/12.5mg Tablet is typically available in standard blister strip packaging. Check the product page for current availability and stock status.

Is it safe to order this medication from an online pharmacy instead of buying in-store?
Yes, ordering from a licensed and verified online pharmacy is a safe, regulated way to purchase this product, provided a valid prescription is submitted and the item is stored and shipped under proper conditions.

How should I store the tablets while waiting for delivery or after they arrive?
Keep the tablets at room temperature, away from direct sunlight and heat, and store them in their original packaging once they arrive.

What payment and order tracking options are available for Singapore customers?
Our online pharmacy supports major payment methods and provides order tracking, so you can follow your purchase from checkout through to delivery in Singapore.

Who can I contact if I have questions about my order before or after purchasing, especially given this is a long-term blood pressure medication?
Our customer support and pharmacist team are available to assist with questions about ordering, delivery, or general product information. Since blood pressure treatment is often long-term, consider planning your reorder timing ahead to avoid interruptions in treatment.