Calcium Leucovorin

Uses of Calcium Leucovorin

Calcium Leucovorin/Calcium Folinate is commonly used to treat Colorectal Cancer, Harmful Effects Of Methotrexate, Methotrexate Toxicity and Megaloblastic Anaemia

How Calcium Leucovorin Works

Calcium Folinate works by entering the cells and stabilises the binding of 5-dUMP with thymidylate synthetase which enhances the fluorouracil activity while neutralising the effects of a folic acid antagonist such as methotrexate.

Side Effects of Calcium Leucovorin

Rash, Allergic reaction, Itchiness, Nausea, Vomiting, Fever, Reddening of the skin

Information About Calcium Leucovorin

Calcium Leucovorin is a folinic acid derivative used as a cytotoxic rescue agent after high-dose methotrexate therapy and as an adjunct in fluorouracil-based colorectal cancer chemotherapy in Singapore. Available as an oral tablet or intravenous infusion dosed according to the treating oncologist's chemotherapy rescue protocol, it is HSA-registered and available on prescription only in Singapore. It replenishes active folate pools in normal tissues to counteract methotrexate-induced toxicity while enhancing fluorouracil's antineoplastic efficacy through thymidylate synthase complex stabilisation. A valid doctor's consultation is required before dispensing. Order Calcium Leucovorin online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Calcium Leucovorin is right for you.

Calcium Leucovorin is a medication commonly used to reduce the toxic effects of certain chemotherapy medications and to support the treatment of specific cancers and folate deficiency conditions. It works by providing an active form of folic acid that helps protect healthy cells and support normal cell function. Calcium Leucovorin belongs to a class of medications known as folate analogues and rescue agents and is widely used in oncology and supportive care. Find affordable Calcium Leucovorin options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Calcium Leucovorin tailored to your health needs. Find the best prices for affordable Calcium Leucovorin tablets and injections at DoctorOnCall Singapore.

Warnings

Kidney Use With Care

Calcium Leucovorin is excreted through urine and feces thus in patient with renal impairment, dosage adjustment may be needed to avoid toxicity of the compound.

Alcohol Safe

There is no known or previous data on the interaction between alcohol and Calcium Leucovorin. The side effects profile also suggest there is low likelihood of augmentation of either substances side effects.

Pregnancy Not Safe

Although there are animal studies conducted with higher dose given and showing no adverse effects on reproduction and pregnancy, there are limited human data to suggest the same. It is, therefore, should only be used when the benefits outweigh the risks.

Driving Generally Safe

There is no contraindication for the use of Calcium Leucovorin before driving. The side effects profile also suggest no contraindication for driving.

Liver Limited Data

Calcium Leucovorin is metabolised by the liver and in those with liver impairment, dosage adjustment may be required.

Lactation Limited Data

It is not known if Calcium Leucovorin is excreted into human breastmilk or not. It is therefore should be used with caution.

Written by

Dr. Adeline Carol Peters, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang, Doctor of Medicine (MD), University of Mansoura - Manchester