Cilastatin

Uses of Cilastatin

Cilastatin is primarily used as an adjunct medication to prevent renal (kidney) damage from the nephrotoxic effects of certain antibiotics, particularly imipenem, by inhibiting their renal metabolism.

How Cilastatin Works

Cilastatin acts by inhibiting the renal dehydropeptidase enzyme, which breaks down certain antibiotics like imipenem. By inhibiting this enzyme, cilastatin helps to maintain therapeutic levels of imipenem in the urine, reducing the risk of kidney damage.

Side Effects of Cilastatin

Common side effects may include nausea, vomiting, diarrhea, headache, and allergic reactions. Serious side effects can include seizures, hallucinations, and severe skin reactions. Consult a healthcare professional if any severe side effects occur.

Information About Cilastatin

Cilastatin is a renal dehydropeptidase inhibitor used exclusively in combination with imipenem to prevent its renal tubular degradation in Singapore. Available only as a fixed intravenous combination with imipenem administered under clinical supervision, it is HSA-registered and available on prescription only in Singapore. Without cilastatin, imipenem is rapidly hydrolysed in the kidney to a nephrotoxic metabolite — cilastatin's presence preserves imipenem's urinary concentrations and eliminates its renal toxicity simultaneously. A valid doctor's consultation is required before dispensing. Order Cilastatin online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Cilastatin is right for you.


Cilastatin is a medication commonly used in combination with certain antibiotics, such as imipenem, to help treat serious bacterial infections. It works by preventing the breakdown of the antibiotic in the kidneys, allowing the antibiotic to remain effective for a longer period in the body. Cilastatin belongs to a class of medications known as renal dehydropeptidase inhibitors and is widely used in hospital and infectious disease care. Find affordable Cilastatin options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Cilastatin tailored to your health needs. Find the best prices for affordable Cilastatin injections at DoctorOnCall Singapore.


Warnings

Kidney Safe If Prescribed

Cilastatin is generally safe for use in individuals with normal kidney function when prescribed appropriately. However, caution is advised in patients with pre-existing kidney issues, and dosage adjustments may be necessary.

Alcohol Limited Data

Limited data are available regarding the interaction of Cilastatin with alcohol. Caution is advised, and it is recommended to consult with a healthcare professional before combining the two.

Pregnancy Limited Data

There is limited data on the safety of Cilastatin during pregnancy. Consultation with a healthcare provider is recommended to assess potential risks and benefits.

Driving Use With Care

Caution is advised while driving or operating machinery, as Cilastatin may cause dizziness or drowsiness in some individuals. It is essential to assess individual response before engaging in activities that require alertness.

Liver Safe If Prescribed

Safe use of Cilastatin has been observed when used as prescribed, with no significant liver-related concerns reported.

Lactation Limited Data

Limited data are available regarding the safety of Cilastatin during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester