I noticed that after taking entacapone, my urine become reddish in colour. Should I be worried?

entacapone might cause darker discolouration (red, brown, or black) of your saliva, urine and sweat. This is harmless, however your clothing and bedsheet may become stained.

Entacapone

Uses of Entacapone

Entacapone is commonly used to treat Parkinson's Disease

How Entacapone Works

Entacapone is an catechol-O-methyl transferase (COMT) inhibitors given in combination with levodopa as inhibiting the COMT enzyme in the peripheral tissues decreases the conversion of levodopa to 3-O-methyldopa (3-OMD) and leads to higher availability and clinical response of levodopa for the brain.

Side Effects of Entacapone

Nausea, Vomiting, Abdominal pain, Constipation, Diarrhea, Dry mouth, Insomnia, Dyskinesia, Parkinsonism, Dizziness, Somnolence, Dystonia, Hyperkinesia, Urine discoloration, Ischaemic heart disease

Information About Entacapone

Entacapone is a peripheral catechol-O-methyltransferase inhibitor used as adjunct therapy to levodopa in Parkinson's disease to extend its duration of action in Singapore. Available as a 200mg oral tablet taken with each levodopa dose up to a maximum of eight times daily, it is HSA-registered and available on prescription only in Singapore. It reduces end-of-dose motor wearing-off by blocking peripheral levodopa degradation, allowing more levodopa to reach the brain at each dose — patients should be warned that urine may turn brownish-orange, a harmless side effect. A valid doctor's consultation is required before dispensing. Order Entacapone online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Entacapone is right for you.

Entacapone is a medication commonly used to help manage symptoms of Parkinson’s disease by prolonging the effects of levodopa treatment. It works by blocking the COMT enzyme, which helps reduce the breakdown of levodopa in the body and increases its availability in the brain. Entacapone belongs to a class of medications known as catechol-O-methyltransferase (COMT) inhibitors and is widely used in Parkinson’s disease management. Find affordable Entacapone options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Entacapone tailored to your health needs. Find the best prices for affordable Entacapone tablets at DoctorOnCall Singapore.

Warnings

Kidney Safe If Prescribed

The excretion of Entacapone is not affected in patients with kidney disease unless they are on dialysis. Dose adjustment is not indicated in patients with kidney disease without dialysis. Please consult your doctor before using it.

Alcohol Not Advisable

It is unsafe to consume alcohol with Entacapone because Alcohol can exaggerate the nervous system side effects of Entacapone such as dizziness and dyskinesia.

Pregnancy Not Safe

Entacapone may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may outweigh the risk. Please consult your doctor before using it.

Driving Not advisable

Entacapone may cause side effects such as dizziness and somnolence all of which could affect your ability to concentrate and drive. Do not drive unless you're feeling well.

Liver Limited Data

Entacapone should be used with caution in patients with liver disease. Dose adjustment of Entacapone may be needed. Please consult your doctor before using it.

Lactation Limited Data

Entacapone is excreted into the breastmilk during animal studies. However, its effect on feeding infants is largely unknown. Hence, Entacapone is not recommended for use in breastfeeding women.