Methotrexate

Uses of Methotrexate

Methotrexate is commonly used to treat Blood Cancer, Breast Cancer, Head And Neck Cancer, Lung Cancer, Non Hodgkin Lymphoma Nhl, Psoriasis, Rheumatoid Arthritis, Choriocarcinoma, Mycosis Fungoides, Crohn's Disease, Osteosarcoma

How Methotrexate Works

Methotrexate which is a folic acid antagonist works by inhibiting the enzymes responsible for the building blocks of DNA hence blocking the DNA synthesis.

Side Effects of Methotrexate

Mouth ulcer, Skin rash, Balding of the head, Joint pain, Anaemia, Nausea, Vomiting, Fatigue, Dizziness

Information About Methotrexate

Methotrexate is a folate antimetabolite used to treat rheumatoid arthritis, psoriasis, and certain malignancies in Singapore. Available as a 2.5mg–25mg oral tablet or subcutaneous injection taken once weekly, it is HSA-registered and available on prescription only in Singapore. Folic acid supplementation on non-methotrexate days is mandatory to reduce the risk of mucositis, hepatotoxicity, and haematological toxicity — patients must understand that methotrexate is taken once weekly, not daily, to prevent life-threatening overdosage. A valid doctor's consultation is required before dispensing. Order Methotrexate online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Methotrexate is right for you.

Methotrexate is a medication commonly used to treat autoimmune conditions such as rheumatoid arthritis and psoriasis, as well as certain types of cancer. It works by interfering with the growth of rapidly dividing cells and modulating immune system activity, helping reduce inflammation and disease progression. Methotrexate belongs to a class of medications known as antimetabolites and disease-modifying antirheumatic drugs (DMARDs) and is widely used in rheumatology, dermatology, and oncology care. Find affordable Methotrexate options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Methotrexate tailored to your health needs. Find the best prices for affordable Methotrexate tablets, injections, and oral solutions at DoctorOnCall Singapore.

Warnings

Kidney High Risk

Dosage adjustment is needed for patients with mild to moderate renal impairment and is contraindicated for patients with severe renal impairment.

Alcohol Not Advisable

Consumption of alcohol with Methotrexate may potentiates the hepatotoxicity of the latter.

Pregnancy Not Safe - High Risk

Methotrexate is strictly contraindicated for a pregnant woman. Effective contraception is advisable in child-bearing age woman if the treatment is started.

Driving Not advisable

It is not advisable to drive when under Methotrexate treatment due to its potential side effects such as fatigue and dizziness which can affect the ability to concentrate and drive.

Liver Use With Care

Dosage adjustment is needed for patients with hepatic impairment based on their bilirubin value. It is contraindicated to be used if the bilirubin value is more than 5mg/dL.

Lactation Not Advisable

Methotrexate is present in human breastmilk and because of the potential toxicity towards the nursing infants, it is contraindicated to be used during breastfeeding.

Written by

Dr. Adeline Carol Peters, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang, Doctor of Medicine (MD), University of Mansoura - Manchester