Palbociclib

Uses of Palbociclib

Palbociclib is commonly used to treat hormone receptor positive breast carcinoma.

How Palbociclib Works

Palbociclib is a reversible, selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1, CDK 4 and 6 are enzymes in the multiple signalling pathways of tumour cell proliferation. Therefore, blocking progression from G1 into S phase of the cell cycle.

Side Effects of Palbociclib

Low white blood cell count, Susceptible to infections, Fatigue, Nausea, Stomatitis, Low red blood cell count, Alopecia, Rash, Diarrhea, Vomiting, Decreased appetite, Vision blurred

Information About Palbociclib

Palbociclib is a CDK4/6 inhibitor used to treat hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in combination with endocrine therapy in Singapore. Available as a 75mg–125mg oral capsule taken once daily for 21 consecutive days followed by 7 days off per cycle, it is HSA-registered and available on prescription only in Singapore. Full blood count must be monitored before each cycle as neutropenia is the most common dose-limiting toxicity, occurring in over 60% of patients and requiring dose adjustment in clinically significant cases. A valid doctor's consultation is required before dispensing. Order Palbociclib online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Palbociclib is right for you.

Palbociclib is a medication commonly used to treat certain types of hormone receptor-positive, HER2-negative breast cancer by helping slow the growth and spread of cancer cells. It works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are proteins involved in cell division and tumour growth. Palbociclib belongs to a class of medications known as CDK4/6 inhibitors and is widely used in targeted cancer therapy and oncology care. Find affordable Palbociclib options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Palbociclib tailored to your health needs. Find the best prices for affordable Palbociclib capsules and tablets at DoctorOnCall Singapore.

Warnings

Kidney Safe If Prescribed

Palbociclibs's pharmacodynamic is not significantly affected in patients with kidney disease. Dose adjustment of Palbociclib may not be needed. Please consult your doctor before using it.

Alcohol Safe

Consuming alcohol in moderation does not seem to cause pharmacodynamic changes with Palbociclib. However, please consult your doctor before using it,

Pregnancy Limited Data

Palbociclib may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The medication is not recommended for use in pregnant women. Please consult your doctor before using it.

Driving Not advisable

Palbociclib may cause side effects of blurred vision and fatigue all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.

Liver Limited Data

Palbociclib should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Palbociclib may be needed in severe liver disease. Please consult your doctor before using it.

Lactation Limited Data

Data of Palbociclib excretion into breast milk and its potential adverse effect on feeding baby is largely unknown. Please consult your doctor before using it.

Written by

Dr. Adeline Carol Peters, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang, Doctor of Medicine (MD), University of Mansoura - Manchester