Perampanel

Uses of Perampanel

Perampanel is commonly used to treat Seizures

How Perampanel Works

Perampanel works by non-competitively antagonize the AMPA glutamate receptor of the post-synaptic neurons and reduce neuronal excitation by blocking glutamate in the central nervous system.

Side Effects of Perampanel

Dizziness, Somnolence, Fatigue, Drowsiness, Vertigo, Anxiety, Confusion, Nausea, Vomiting, Blurred vision

Information About Perampanel

Perampanel is a selective AMPA receptor antagonist used as adjunctive therapy for focal and generalised tonic-clonic seizures in Singapore. Available as a 2mg–12mg oral tablet taken once daily at bedtime, it is HSA-registered and available on prescription only in Singapore. Its novel mechanism — selectively blocking ionotropic AMPA glutamate receptors — is distinct from all other anticonvulsants, providing additive seizure control in refractory epilepsy with particular caution required for psychiatric side effects including irritability and aggression. A valid doctor's consultation is required before dispensing. Order Perampanel online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Perampanel is right for you.


Perampanel is a medication commonly used to treat epilepsy and certain types of seizures by helping stabilise electrical activity in the brain. It works by blocking AMPA receptors, which are involved in the transmission of excitatory nerve signals that can trigger seizures. Perampanel belongs to a class of medications known as antiepileptic agents and is widely used in neurology and seizure management. Find affordable Perampanel options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Perampanel tailored to your health needs. Find the best prices for affordable Perampanel tablets and oral suspensions at DoctorOnCall Singapore.


Warnings

Kidney High Risk

Perampanel should be used with caution in people with mild renal impairment and is contraindicated for those with moderate to severe renal impairment.

Alcohol Not Advisable

Consuming alcohol when taking Perampanel is strictly contraindicated due to potential worsening of side effect on the central nervous system.

Pregnancy Limited Data

Animal reproductive studies did not indicate fetal harm or toxicity but do show embryological toxicity. Human pregnancy data is limited and thus it is not recommended for Perampanel to be used during pregnancy.

Driving Not advisable

It is not advisable to drive when under Perampanel treatment due to its potential side effects such as fatigue and dizziness which can affect the ability to concentrate and drive.

Liver Limited Data

Perampanel should be used with caution in people with mild to moderate hepatic impairment together with dosage adjustment and is contraindicated for those with severe hepatic impairment.

Lactation Limited Data

It is not known whether Perampanel is excreted into human breastmilk or not. Due to its potential toxicity, Perampanel is not advisable to be used during breastfeeding. If being used during breastfeeding, alternative to the latter should be sought.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester

  • Products
    Available medicines with Perampanel
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Prescription Medicine
Fycompa 4mg Tablet
Fycompa 4mg Tablet
Sold: 7

Starts from

SGD128.32
Prescription Medicine
doctoroncall benefits
Fycompa (Perampanel) 2mg Tablet
Sold: 1

Starts from

SGD16.33