Pethidine

Uses of Pethidine

Pethidine is commonly used as anesthesia, and control of moderate to severe pain

How Pethidine Works

Pethidine is an opioid analgesic. It activates opioid receptors in the nervous system by mimicking endogenous opioids which reduce the release of neurotransmitters and postsynaptic neuronal activity in the spinal cord leading to the prevention of transmission of pain impulses.

Side Effects of Pethidine

Hypotension, fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, rash, urticaria, nausea, vomiting, constipation, anorexia, stomach cramps, ureteral spasms, decreased urination, pain at inj site, physical and psychological dependence.

Information About Pethidine

Pethidine is an opioid analgesic used to treat moderate to severe acute pain and as an obstetric analgesic during labour in Singapore. Available as an intramuscular or intravenous injection of 25mg–100mg administered under clinical supervision, it is HSA-registered and available on prescription only in Singapore. Unlike morphine, pethidine produces a toxic active metabolite norpethidine that accumulates with repeated doses and can cause seizures — it is therefore unsuitable for chronic pain management and should be limited to short acute use. A valid doctor's consultation is required before dispensing. Order Pethidine online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Pethidine is right for you.


Pethidine is a medication commonly used to manage moderate to severe pain, including pain associated with surgery, injury, and childbirth. It works by binding to opioid receptors in the brain and nervous system, helping reduce the perception of pain and improve comfort. Pethidine belongs to a class of medications known as opioid analgesics and is widely used in pain management and obstetric care. Find affordable Pethidine options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Pethidine tailored to your health needs. Find the best prices for affordable Pethidine injections and other approved formulations at DoctorOnCall Singapore.


Warnings

Kidney Use With Care

Pethidine should be used with caution in patients with kidney impairment. Dose adjustment of Pethidine may be needed. Please consult your doctor.

Alcohol Not Advisable

It is not advisable to drink alcohol with Pethidine as alcohol it can cause enhanced sedative and hypotensive effects of the medication.

Pregnancy Not Safe

Pethidine may be unsafe to use especially during early pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Pethidine may cause side effects such as delaying reaction time, dizziness or sleepiness, all of which could affect the ability to concentrate and drive.

Liver Use With Care

Pethidine should be used with caution in patients with chronic liver disorder. Dose adjustment of Pethidine may be needed. Please consult your doctor.

Lactation Not Advisable

Pethidine is shown to be excreted in breast milk. It is not advisable for women to breastfeed while consuming Pethidine because of its potential adverse drug effects on infants.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester