Can I become resistant to pyrazinamide?

Resistance can happen if the bacteria gets modified in your body and stops reacting to the medications. This is called drug resistance. Drug resistance is uncommon if pyrazinamide is used with other tuberculosis medication.

Does pyrazinamide affect birth control?

pyrazinamide has no known integration with birth control medications. However, combination treatments for tuberculosis containing rifampin is said to have some decrease in effectiveness of oral contraceptives.

Is pyrazinamide bacteriostatic or bactericidal?

pyrazinamide is known to be a bacteriostatic medication. pyrazinamide stops the growth of bacteria by disrupting the formation of protective outer cell which is essential for the bacteria to grow.

Pyrazinamide

Uses of Pyrazinamide

Pyrazinamide is commonly used in the treatment of Tuberculosis (TB)

How Pyrazinamide Works

Pyrazinamide is an Anti-Tuberculosis agent. Pyrazinamide mechanism of action reduces the pH of the environment, affecting the growth of M. tuberculosis due to suboptimal environment for its activity.

Side Effects of Pyrazinamide

Hyperuricaemia leading to acute gout, Anorexia, Nausea, Vomiting, Aggravation of peptic ulcer, Arthralgia, Malaise, Fever, Anaemia, Thrombocytopenia, Dysuria, Hepatotoxicity.

Information About Pyrazinamide

Pyrazinamide is a bactericidal nicotinamide analogue used in the intensive phase of tuberculosis treatment in Singapore. Available as a 500mg oral tablet taken once daily as part of the standard four-drug TB regimen for the initial two months, it is HSA-registered and available on prescription only in Singapore. It is active against semi-dormant mycobacteria in acidic intracellular macrophage environments where other first-line agents are less effective, making it essential for sterilising the intracellular mycobacterial reservoir and preventing relapse. A valid doctor's consultation is required before dispensing. Order Pyrazinamide online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Pyrazinamide is right for you.

Pyrazinamide is an antibiotic medication commonly used as part of combination therapy to treat tuberculosis (TB). It works by targeting and killing Mycobacterium tuberculosis bacteria, helping shorten the duration of TB treatment when used with other anti-tuberculosis medications. Pyrazinamide belongs to a class of medications known as antitubercular agents and is widely used in infectious disease care. Find affordable Pyrazinamide options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Pyrazinamide tailored to your health needs. Find the best prices for affordable Pyrazinamide tablets and anti-tuberculosis treatment formulations at DoctorOnCall Singapore.

Warnings

Kidney Use With Care

Pyrazinamide should be used with caution in patients with kidney impairment. Dose adjustment of Pyrazinamide may be needed. Please consult your doctor.

Alcohol Not Advisable

Avoid taking Pyrazinamide with alcohol as consuming both substances simultaneously potentiate hepatotoxicity.

Pregnancy Not Safe

No well- controlled studies in pregnant women. Pyrazinamide benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Driving Generally Safe

Pyrazinamide usually does not affect the ability to drive. Do not drive unless you are feeling well.

Liver Use With Care

Pyrazinamide is contraindicated in patients with severe hepatic impairment. Dose adjustment of Pyrazinamide is necessary. Please consult your doctor.

Lactation Not Advisable

Pyrazinamide is shown to be excreted in breast milk.but its potential adverse drug effects on infants is largely unknown.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang, Doctor of Medicine (MD), University of Mansoura - Manchester