Sacubitril

Uses of Sacubitril

Sacubitril is commonly used to treat Heart Failure

How Sacubitril Works

Sacubitril is a prodrug of Sacubitrilat which inhibits neprilysin that is responsible for breaking down natriuretic peptides. The increase of the natriuretic peptides can aid in decreasing the workload of the heart. Sacubitril is usually used in combination with Valsartan.

Side Effects of Sacubitril

Hypotension, Hyperkalaemia/Hypokalaemia, Decreased kidney function, Anaemia, Diarrhea, Heartburn, Hypoglycaemia, Dizziness, Headache, Vertigo

Information About Sacubitril

Sacubitril is a neprilysin inhibitor used exclusively in combination with valsartan as the novel ARNI class therapy for chronic heart failure with reduced ejection fraction in Singapore. Available only as a fixed combination with valsartan (sacubitril/valsartan) taken twice daily, it is HSA-registered and available on prescription only in Singapore. A mandatory 36-hour washout from ACE inhibitor therapy is required before starting sacubitril/valsartan to prevent potentially life-threatening angioedema from combined neprilysin and ACE inhibition elevating bradykinin levels. A valid doctor's consultation is required before dispensing. Order Sacubitril online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Sacubitril is right for you.

Sacubitril is a medication commonly used in combination with valsartan to treat chronic heart failure and help reduce the risk of cardiovascular death and hospitalisation. It works by inhibiting neprilysin, an enzyme that breaks down beneficial peptides involved in regulating blood pressure, fluid balance, and heart function. Sacubitril belongs to a class of medications known as neprilysin inhibitors and is widely used in cardiovascular care. Find affordable Sacubitril-containing treatment options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Sacubitril tailored to your health needs. Find the best prices for affordable Sacubitril combination tablets and heart failure treatment formulations at DoctorOnCall Singapore.

Warnings

Kidney Use With Care

Dose adjustment is needed for patients with moderate to severe (eGFR<30ml/min/1.73m2) kidney impairment. It is not recommended to be used in patients with end-stage renal disease as there are no clinical data in this group of patients.

Alcohol Not Advisable

Alcohol may further lower the blood pressure caused by Sacubitril. Alcohol can also cause palpitation which will increase the workload of the heart, further worsen the heart function. Thus, it is not advisable to consume alcohol and Sacubitril concomitantly.

Pregnancy Limited Data

Human studies have shown reproductive toxicities such as reduced kidney function of the newborn. Thus, it is not advisable to be used during pregnancy. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Sacubitril may cause side effects such as dizziness or tiredness, all of which could affect your ability to concentrate and drive.

Liver Limited Data

Dose adjustment is needed for patients with moderate hepatic impairment. Sacubitril is contraindicated in patients with severe liver impairment.

Lactation Limited Data

Excretion of Sacubitril is not known in human breast milk. Thus, it is not advisable to be used during breastfeeding as risks cannot be excluded. Please consult your doctor.

Written by

Dr. Adeline Carol Peters, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang, Doctor of Medicine (MD), University of Mansoura - Manchester