Sirolimus

Uses of Sirolimus

Sirolimus is commonly used to treat Lymphangiomyomatosis and used as Prevention Of Kidney Transplant Rejection.

How Sirolimus Works

Sirolimus is a macrolide that is able to suppress our immune mediators, subsequently suppresses the over-activation of our immune system in conditions such as Lymphangiomyomatosis and after the kidney transplant procedure.

Side Effects of Sirolimus

Increased risk of infection, Hypokalaemia, Dyslipidaemia, Hypophosphataemia, Hyperglycaemia, Headache, Gut disturbances, Liver dysfunction, Skin rash, Joint pain, Proteinuria, Menstrual disorder, Oedema, Anaemia/Low platelet/Low white blood cell

Information About Sirolimus

Sirolimus is an mTOR inhibitor used to prevent organ transplant rejection and treat lymphangioleiomyomatosis in Singapore. Available as a 0.5mg–5mg oral tablet or solution taken once daily, it is HSA-registered and available on prescription only in Singapore. Unlike calcineurin inhibitors, sirolimus is not nephrotoxic — however, it impairs wound healing and should be discontinued before and after surgery, and its use with cyclosporine requires careful monitoring for additive nephrotoxicity and drug interactions. A valid doctor's consultation is required before dispensing. Order Sirolimus online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Sirolimus is right for you.


Sirolimus is a medication commonly used to prevent organ transplant rejection and to treat certain rare medical conditions by suppressing immune system activity. It works by inhibiting the mammalian target of rapamycin (mTOR), a protein involved in immune cell growth and proliferation, helping reduce the body's immune response. Sirolimus belongs to a class of medications known as mTOR inhibitors and immunosuppressants and is widely used in transplant medicine and specialised care. Find affordable Sirolimus options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Sirolimus tailored to your health needs. Find the best prices for affordable Sirolimus tablets, oral solutions, and specialised treatment formulations at DoctorOnCall Singapore.


Warnings

Kidney Safe If Prescribed

Sirolimus is safe to be used in patients with kidney impairment.

Alcohol Not Advisable

There is no known interaction between alcohol and Sirolimus when used concomitantly. However, it is not advisable to use alcohol during the treatment of Lymphangiomyomatosis and after kidney transplant.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities and there are limited data on the use of Sirolimus in pregnant women. Thus, Sirolimus is not advisable to be used during pregnancy. Please consult your doctor.

Driving Generally Safe

Sirolimus usually does not affect the ability to drive. Do not drive unless you are feeling well.

Liver Use With Care

Caution use and dose adjustment are needed for patients with liver impairment. Please consult your doctor.

Lactation Not Advisable

Excretion of Sirolimus has been found in animal milk but it is unknown in human breast milk. To prevent the potential of adverse effect on breastfed babies, it is advisable not to use Sirolimus during breastfeeding. Please consult your doctor.

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester