Voriconazole

Uses of Voriconazole

Voriconazole is commonly used to treat Fungal Infections and Severe Fungal Infections

How Voriconazole Works

Voriconazole is an antifungal agent which binds to CYP450-dependent 14-alpha sterol demethylase, leading to the inhibition of ergosterol synthesis and destroying the fungal cell membrane.

Side Effects of Voriconazole

Allergy reaction, Visual disturbances, Gut disturbances, Liver dysfunction, Tachycardia, Headache

Information About Voriconazole

Voriconazole is a broad-spectrum triazole antifungal used to treat invasive aspergillosis, candidiasis, and serious fungal infections in immunocompromised patients in Singapore. Available as a 200mg oral tablet taken twice daily on an empty stomach or as an intravenous infusion, it is HSA-registered and available on prescription only in Singapore. Therapeutic drug monitoring of voriconazole trough levels is essential due to highly variable pharmacokinetics from CYP2C19 genetic polymorphism — sub-therapeutic levels lead to treatment failure while supra-therapeutic levels cause serious neurotoxicity and hepatotoxicity. A valid doctor's consultation is required before dispensing. Order Voriconazole online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Voriconazole is right for you.


Voriconazole is an antifungal medication commonly used to treat serious fungal infections such as invasive aspergillosis and infections caused by Candida species. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby stopping fungal growth and leading to cell death. Voriconazole belongs to a class of medications known as triazole antifungals and is widely used in infectious disease and hospital care. Find affordable Voriconazole options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Voriconazole tailored to your health needs. Find the best prices for affordable Voriconazole tablets, oral suspension, and intravenous formulations at DoctorOnCall Singapore.


Warnings

Kidney Use With Care

Oral preparations of Voriconazole are safe to use in patients with kidney impairment. However, intravenous preparations of Voriconazole has to be avoided and switch to oral preparation in patients with creatinine clearance less than 50ml/min.

Alcohol Safe

There is no known interaction between Voriconazole and alcohol. However, possibility of interactions cannot be excluded. Please consult your doctor.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity but there are limited data of Voriconazole on pregnant women. Thus, it is not advisable during pregnancy unless the benefits outweigh the risks. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Voriconazole may cause side effects such as brief visual disturbance or sensitive to bright light, all of which could affect your ability to concentrate and drive.

Liver Limited Data

Dose adjustment of Voriconazole may be needed in patients with mild to moderate liver impairment. Caution use has to be exercised in patients with severe liver impairment as there are no studies of Voriconazole in this group of patients.

Lactation Limited Data

Excretion of Voriconazole into human milk has not been investigated. It is not advisable during breastfeeding. Please consult your doctor.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester