Zonisamide

Uses of Zonisamide

Zonisamide is commonly used to treat Epilepsy

How Zonisamide Works

Zonisamide is a sulfonamide so it seems to not relate to any seizure medications. However, it has an unknown mechanism for controlling epilepsy. It is hypothesized to block sodium and voltage-sensitive calcium channels which will then prevent neuronal depolarization that helps in controlling partial seizure.

Side Effects of Zonisamide

Abdominal pain, Altered bowel habit, Dry mouth, Taste disturbance, Headache, Dizziness, Rash, Neurological disturbance

Information About Zonisamide

Zonisamide is a broad-spectrum anticonvulsant used to treat focal and generalised epilepsy as monotherapy or adjunctive therapy in Singapore. Available as a 25mg–100mg oral capsule taken once to twice daily, it is HSA-registered and available on prescription only in Singapore. Adequate hydration is important during therapy as zonisamide's carbonic anhydrase inhibition reduces urinary citrate, increasing kidney stone risk — patients should maintain a minimum of 1.5 litres of fluid daily and report any flank pain or haematuria promptly. A valid doctor's consultation is required before dispensing. Order Zonisamide online at DoctorOnCall Singapore with same-day delivery available. Speak to a DoctorOnCall physician today to check if Zonisamide is right for you.


Zonisamide is a medication commonly used to treat epilepsy by helping control and prevent seizures. It works by stabilising electrical activity in the brain through modulation of sodium and calcium channels and enhancing inhibitory neurotransmitter activity. Zonisamide belongs to a class of medications known as antiepileptic drugs (AEDs) and is widely used in neurology care. Find affordable Zonisamide options from trusted brands at DoctorOnCall.

Conclusion

Consult our doctors online for safe and effective use of Zonisamide tailored to your health needs. Find the best prices for affordable Zonisamide capsules at DoctorOnCall Singapore.


Warnings

Kidney Use With Care

Dose adjustment is required for patient with kidney impairment. Its usage is not advisable in patients with severe kidney impairment (GFR <50mL/min).

Alcohol Not Advisable

It is unsafe to consume alcohol with Zonisamide. Taking Zonisamide with alcohol may have additive effects on causing dizziness, drowsiness and difficulty concentrating.

Pregnancy Not Safe

Zonisamide may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies showing potential risks. The use of Zonisamide is not advisable during pregnancy unless clearly necessary. Please consult your doctor.

Driving Not advisable

There are no studies of Zonisamide on the effect of ability to drive. Do not drive unless you are well.

Liver Use With Care

Dose adjustment of Zonisamide is required for patient with liver impairment. Its usage is not advisable in patients with severe liver impairment.

Lactation Not Advisable

Zonisamide is shown to be excreted in human milk and may pose potential risks to breastfed babies. A decision must be made whether to discontinue breastfeeding or discontinue Zonisamide. Please consult your doctor.

Frequently Asked Questions

Written by

Dr. Adeline Carol Peters

, Bachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Reviewed by

Dr. Mohd Izzat Amir Bin Awang

, Doctor of Medicine (MD), University of Mansoura - Manchester

  • Products
    Available medicines with Zonisamide
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Prescription Medicine
Zonegran (Zonisamide) 100mg Tablet
Zonegran (Zonisamide) 100mg Tablet
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SGD135.89